Caenorhabditis Elegans Homologues

 

Vertebrate Protein
C. Elegans Protein
Function
Sequence
Identity
Reference
ß-Catenin

WRM-1
BAR-1
HMP-2

WRM-1: Opposes Wnt signalling

BAR-1: Patterning events during larval development

HMP-2: Cellular adhesion

WRM-1: 15%

BAR-1: 25%

HMP-2: 26%


Tcf
POP-1
Repressor in Wnt pathway
54%
(within HMG Box)

Alpha-Catenin

HMP-1
Binds and bundles actin filaments
35-38%

ß-Catenin / ARM

HMP-2
Cellular adhesion
26%

Classical Cadherins
HMR-1
Interacts with HMP-2
20-25%