Caenorhabditis Elegans Homologues
|
Vertebrate
Protein
|
C.
Elegans Protein
|
Function
|
Sequence
Identity |
Reference
|
|
ß-Catenin
|
WRM-1 BAR-1 HMP-2 |
WRM-1:
Opposes Wnt signalling
BAR-1: Patterning events during larval development HMP-2: Cellular adhesion |
WRM-1:
15% HMP-2: 26% |
|
|
Tcf |
POP-1
|
Repressor in Wnt pathway |
54%
(within HMG Box) |
|
Alpha-Catenin |
HMP-1
|
Binds and bundles actin filaments |
35-38%
|
|
|
ß-Catenin / ARM |
HMP-2 |
Cellular adhesion |
26%
|
|
|
Classical Cadherins |
HMR-1
|
Interacts with HMP-2 |
20-25%
|